![]() His long-term manager Bill Cayton was engaged in a legal battle with promoter Don King, while Trump - an admirer of Tyson long before his presidency came to pass - acted as an adviser to the young fighter and was posturing to ensure the biggest fights were held at his hotel and casino resorts. He had parted with trainer Kevin Rooney, while his marriage to actress Robin Givens had ended in an ugly mix of public scrutiny, restraining orders and ultimately divorce. His trainer, mentor and father-figure Cus D'Amato had died five years earlier. The turmoil in his life saw him describe his regime of three training sessions a day as "stress relief".Īt the time, Tyson's life was chaotic. If his mother's passing was not enough, Douglas had also split from his wife. "My manager called me and asked if I still wanted to fight," recalls Douglas. She had told friends her son was in a good place mentally to cause an upset. Lula Pearl was the first person to instruct her son to stand up to childhood bullies. In the build-up, punters in Las Vegas placed bets on Tyson of $93,000 to win $3,000 and $54,000 to win $2,000.ĭouglas' mother had died 23 days before the showdown. Tyson was good friends with Donald Trump at the timeĭouglas was 42-1 in a two-horse race. "Opponents would look like they were walking to the gallows," adds Costello. His previous world-title defence had lasted 96 seconds. Now he brought fear to others and, as the undisputed heavyweight champion, with 37 wins and no defeats, had most men beaten before the sound of the opening bell. Tyson, then 23, had shaken off the kind of fear that saw him cry before teenage bouts. Their back pages would soon be bursting with upset and scandal fed back from Japan's Tokyo Dome, where the fight took place at 9am local time. The front pages of newspapers on 11 February 1990 were occupied by Nelson Mandela's imminent release from prison in South Africa. Back then it was a case of how do you go away and prove it," recalls BBC Sport boxing correspondent Mike Costello. "I had a call the next day from someone who told me the result. As a result, the stunning upset was largely unseen. In the UK, Tyson's previous title fights had been shown on terrestrial television but the Douglas bout was only available via Sky, which had begun broadcasting a year earlier and then reached relatively small numbers. Listen: 5 Live Boxing with Costello & Bunce - Tyson v Douglas: the biggest upset ever?.Thirty years have passed since the unthinkable occurred. "When I saw him go down, it felt like somebody lied," the lyrics read. It was a day where millions of dollars disappeared for those with skin in the game.ĭecades later, The Killers wrote a song about the chaos. ![]() It was a day where desperate corner men made icepacks out of rubber gloves, or condoms, depending on who you believe. “I’d love to finish it in the ring, one way or another.It was a day shaped by turmoil. “I was sad to see him quit on the school,’’ McBride, 47, told USA TODAY Sports. More: A look back at Mike Tyson's last, inglorious pro fight The two fought June 11, 2005, when during the last professional fight of his career Tyson refused to come out for the seventh round. Kevin McBride is yet another boxer who said he’d like a rematch with Tyson. ![]() “A couple of guys that were past their prime but put a good effort in there. That’s about it.’’ĭouglas called Tyson’s fight against Jones at the Staples Center in Los Angeles "pretty impressive.’’ “It was just never presented really, as far as a rematch. “They always ask, ‘Why didn’t you guys have a rematch?’ ‘I’ve been asked about it in casual conversation,’’ Douglas said. More: 6 wild details from the Mike Tyson-Buster Douglas fight Stunning upset: Relive the night Buster Douglas shocked the world by knocking out Mike Tyson 11, 1990 in Tokyo, Douglas knocked him out in the 10th round. Thirty years ago, Douglas was a 42-to-1 underdog heading into his fight against Tyson, who at the time was 37-0 with 33 knockouts. But he said he works with amateur fighters in his hometown of Columbus, Ohio, and could be ready to fight in six to eight weeks. Douglas, 60, has not fought professionally since 1999. ![]()
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![]() There are two different tread patterns for the BFG g-Force COMP-2 A / S +: 6 ribs and 4 ribs. The main differences achieved in the g-Force COMP-2 A / S Plus model through the use of a new generation of rubber compounds are improved grip on snow, dry and wet surfaces, as well as improved handling on wet roads. The sequence of blocks of increased rigidityĪll-season BFGoodrich g-Force Comp-2 A / S provides faster acceleration on wet and dry asphalt in comparison with the main competitors before the main competitors, it breaks on a dry track (the difference is 16 ft) and on a wet road (the difference is14.5 ft) and also has better traction on snow. Reinforced sidewalls reduce rolling distortion and provide quick steering responses. Optimization of tread block stiffness resulted in improved load distribution in the contact patch, and the reinforced "armored" internal structure of g-Force Comp-2 All Season - improved control over the road situation while maintaining ride comfort. Extra-large transverse drainage grooves and beveled blocks provide additional traction on snowy road surfaces. V-shaped sloped shoulder grooves and longitudinal circumferential channels effectively evacuate water from the contact patch, while guaranteeing a good grip on wet asphalt. ![]() The directional tread pattern is also designed to provide excellent all-season traction. This means that the tires of this model retain their first-class grip in all weather conditions. The BFG g-Force Comp-2 A / S tires are manufactured with proprietary UltiGrip technology, which allows the all-season rubber compound with a high silica content to withstand wide temperature fluctuations. But while the Sport Comp-2 tires are only effective in warm weather, the all-season Sport Comp-2 A / S promises high performance in light snow. Since both tires (BF Goodrich g-Force Comp-2 A / S and BF Goodrich g-Force Sport Comp-2) have almost the same name, it goes without saying that their construction is the same. If you know anything about the brand's products, then you are probably familiar with the BFGoodrich g-Force Sport Comp 2, a high-performance summer tire designed for sports cars. The manufacturer has already appeared for the first time in its 2015 premiere, the BFGoodrich g-Force Comp-2 A / S, "the best all-season UHP tires in the entire history of the brand." It is not surprising, because the tire, in addition to the first-class grip on dry and wet asphalt, provides reliable contact with snowy roads in summer. Michelin, which manufactures the BFGoodrich g-Force COMP-2 A / S Plus tires, markets them as "capable of tearing the track and guaranteeing safety even in the most extreme driving conditions." In the lineup, plus tires will replace the 2015 g-Force COMP-2 A / S development, as a reminder of which it was decided to leave the directional tread pattern left unchanged. It should be noted that the good technical properties of the product are very close to the seasonal models, which makes the tires a real breakthrough for this manufacturer. Having passed a large number of tests and tests, the tires have been noted by independent experts as safe, comfortable, and profitable from a financial point of view, due to their all-season features. The tires were introduced in 2015 and immediately became highly sought after by drivers of passenger cars with excellent speed performance. The product of the American company BFGoodrich in the development of all-season models with high-performance characteristics. Mud Terrain tires can generate higher noise levels and tend to carry lower mileage warranties the another tread designs.The BFGoodrich g-Force COMP-2 A / S Plus is an ultra-high performance all-season tire that provides reliable traction in all weather conditions. Mud-Terrain treads are specifically designed with wider tread blocks and higher void ratios to gain traction in off-road conditions. All Terrain tires are suitable for everyday use. There more aggressive tread tends to be less quiet on paved roads. Highway tread patterns deliver a quiet ride.įor light trucks and specialty vehicles, All-Terraintread types provide better off-road traction than standard highway truck tires. These tires can be driven off pavement, but are not ideally suited for off road traction. The tread is optimized for normal everyday driving on paved surfaces. Highway is a tread type unique to SUV and truck tires. Passenger denotes a tread that is suitable for normal use, a good all-round tread for normal driving. TREAD TYPETread Type is an important consideration when choosing a tire.There are four main types: Passenger, Highway, All-Terrain andMud-Terrain. ![]() ![]() In the school library, Harper expands her search to 1962 and comes across a photo taken of The Tremont where a girl is on the porch who looks just like Savannah. She sends Griffin upstairs to pack his room. ![]() Sarah reveals that she’s already called school and the kids won’t be going this week, with plans to resume classes in Chicago when they get back. ![]() “Everything will be fine once we’re back in Chicago,” she reassures Griffin, who says he doesn’t want to move. Griffin comes downstairs to find his mom setting the table for breakfast, learning that his dad hasn’t returned after his fight with Sarah the night before. The librarian also reveals that she’s an expert on local history. The librarian tells her about the library’s extensive collection of microfilm, which includes slides from old Sulphur Springs newspapers. The next morning, Harper gets caught by the school librarian trying to get in two-hours early. Griffin asks his mom if his dad really just admitted he knew Savannah, but Sarah dismisses Griffin, sending him back to his room. What else are you hiding?,” he hears Sarah ask as Ben storms out of the room and down the stairs. Sneaking into the hallway to eavesdrop, he hears his mom say she and the kids are moving back to Chicago, revealing that she believes the hotel is haunted. It turns out she met Chris at Camp Tremont when he offered to help her with her duffel bag on the last day of camp, meaning the boy Harper saw Jess with on her way back to the present was her father.Īt The Tremont, Griffin has started his own online search for a “Great storm of 1960” when he hears his parents fighting. Harper and Jess bond as Jess shares the story of how she first met their dad. It reveals that Harper’s dad’s name was Christopher James Dunn, born in 1977 and died in 2011. Harper uses her phone to search for storms in 1960 and doesn’t realize that Jess has brought her to the cemetery, leading her and Topher to their father’s grave. In the car, Jess tells Harper she needs to make a stop first. Harper tells her mom she wants to go home, telling another lie about an assignment she needs to finish. Harper takes the blame, explaining that it was Griffin who talked her into coming back. Harper starts a new lie to cover for her disappearance with Griffin, saying they were running away together and walked to a bus stop in Rayville. Just as they approach, Jess gets a text from Harper and they head back to The Tremont, never trying to open it. Jess admits it could be from Harper’s shoe, but when the German Shepherd sniffs Harper’s sweatshirt, the police dog leads them right to the hatch. Needing to go backwards through the portal twice to return, on their way out of The Tremont in 1990, Harper sees Jess standing out front with her caboodle in hand talking to a boy holding a big duffel bag.īack in the present, Jess joins Ben and Sarah with the police in the woods where a footprint was found in the dirt. She suggests they go back to the present and check records for 1960 to see if a girl was found after a big storm. Harper accepts defeat, convincing Griffin that the tree must have fallen on the hatch and they won’t be able to open it. It turns out a police officer entered the house when nobody answered the door, which is what scared her.īack in 1960, Griffin is pushing on the hatch while Harper tries to pull the cord to get it to open. Just then, Ben gets a call from Sarah who tells him something strange is going on before letting out a blood curdling scream. She doesn’t accept his apology and Topher interrupts their cold stares by bringing Ben one of Harper’s jackets. ![]() “What did you do to Savannah?,” Jess asks him as he apologizes for blaming her for the camper’s disappearance. “You look like you saw a ghost,” Zoey says as Sarah ushers them into the hallway and down the stairs as the lights flicker.īen is still outside Jess’ house waiting for Topher to bring a piece of clothing of Harper’s for the K-9 search. ![]() She probably expected another word like “Away” to appear, but all it says is “Stay.” A chair rocks behind her and a lamp falls over as Wyatt and Zoey enter to find their mom terrified. Picking up right where we left off, Sarah is looking at the mirror that fogged up with the word “Stay” written in it. ![]() ![]() ![]() Users can share files via email or by saving them to cloud storage services such as OneDrive or SharePoint. Microsoft Excel 2010 download also includes collaboration tools, which make it easy for users to share and collaborate on spreadsheets with others. Users can create a wide range of charts and graphs, including bar charts, pie charts, and line graphs, to visualise data and trends. It comes with over 400 built-in functions, including statistical, financial, and mathematical functions.Īnother powerful feature of Excel 2010 is its charting and graphing capabilities. It allows users to navigate through the software easily and quickly, making it easy to work with large amounts of data.Įxcel 2010 also includes a wide range of features and functions that make it easy for users to perform complex calculations and analysis. ![]() One of the key features of excel 2010 free download is its user-friendly interface. The program allows users to store, organise, manipulate, and analyse data in a convenient and efficient manner. It is a part of the Microsoft Office suite and is widely used in businesses, academic institutions, and personal life. Microsoft Excel 2010 is a spreadsheet program developed by Microsoft Corporation. Whether you are a beginner or an experienced user, the Microsoft Excel 2010 Free Downloads Guide can help you make the most of this powerful spreadsheet program. The guide also includes information on how to activate and register the software, as well as tips for getting started with Excel 2010. Fortunately, Microsoft offers a free download guide that provides step-by-step instructions for downloading and installing Excel 2010.In this article, you will learn ways for microsoft excel 2010 free downloads and discover various Excel 2010 alternatives. If you are new to Excel 2010 or are looking to upgrade from an earlier version, you may be wondering how to download and install it on your computer. With its user-friendly interface and a wide range of features, Excel 2010 makes it easy for users to create, edit, and share spreadsheets. It is an essential tool for businesses, academics, and individuals who need to manage large amounts of data efficiently. Microsoft Excel 2010 is a powerful spreadsheet program that allows users to organise, manipulate, and analyse data. ![]() ![]() ![]() By using valueConsistsOf prop you can change that behavior.What's been checked? ). ![]() Id: '', // used to identify the option within the tree so its value must be unique across all optionsĭefining branch nodes only needs an extra children property: from './utils'įor non-flat & multi-select mode, if a branch node and its all descendants are checked, vue-treeselect will combine them into a single item in the value array, as demonstrated in the following example. The treeview component is a user interface that is used to represent hierarchical data in a tree structure. It aims to provide all the tools necessary to create beautiful content rich applications. To create a radio button node, specify input.type 'radio' on the node’s treeNodeSpec, give the node a name. Vuetify is a Material Design component framework for Vue.js. In this example, you can switch between search modes in the drop. ![]() Use the searchMode property to specify whether items should contain (default), start with, or match the search string. To initialize the node as checked, specify true. To add a search bar to the TreeView and customize the search functionality, do the following: Set the searchEnabled property to true. The default type is ‘leaf’, which will only include leaf nodes in the v-model array, but will render parent nodes as either partially or fully selected.The alternative mode is ‘independent’, which allows one to select parent nodes, but each node is independent of its parent and children. To create a checkbox node, specify input.type 'checkbox' on the node’s treeNodeSpec. Treeview now supports two different selection types. There are 33 other projects in the npm registry using vue-json-tree-view. Start using vue-json-tree-view in your project by running npm i vue-json-tree-view. These two kinds of nodes together compose the tree. Support for checkboxes and radio buttons is built into the treeview. Latest version: 2.1.6, last published: 3 years ago. Here, I'd like to borrow the basic concepts from Computer Science and call the former as branch nodes & the latter as leaf nodes. If you’re looking for the current documentation click here. This is the documentation for an older version of Vue. folder options that are foldable & may have children options, and b. Example of a simple tree view implementation showcasing recursive usage of components. In this article, we’ll look at Vuetify Treeview CustomizationsVuetify is a popular UI framework for Vue apps. The first thing you need to learn is how to define options. Spread the love Related Posts Vuetify Treeview SelectionsVuetify is a popular UI framework for Vue apps. Try the fuzzy matching functionality by typing a few letters. This example demonstrates the most commonly-used features of vue-treeselect. Vue.component('treeselect', VueTreeselect.Treeselect) select vue-ts templatepnpm install progress/kendo-vue-popup. In this way, make sure Vue as a dependency is included before vue-treeselect. Kendo Angular TreeView, How to perform Expand All and Collapse All in Kendo Tree View. If you just don't want to use webpack or any other bundlers, you can simply include the standalone UMD build in your page. Vue JSON Tree View Demo and Blogpost You can check out the demo on JSFiddle and read the Blogpost called Building a JSON Tree View Component in Vue. npm install -save example shows how to integrate vue-treeselect with your Vue SFCs. It's recommended to install vue-treeselect via npm, and build your app using a bundler like webpack. This will install the latest version of vue. We are not going to use any external library to implement it. Keyboard support (navigate using Arrow Up & Arrow Down keys, select option using Enter key, etc.) Implementing nested tree view is pretty simple in vue.js.Delayed loading (load data of deep level options only when needed).Single & multiple select with nested options support.vue-finder is a Vue.js component that renders an OS X Find app style interface to showcase your hierarchical data (e.g. Vue-treeselect is a multi-select component with nested options support for Vue.js. OS X Finder Like Tree Component vue-finder. ![]() ![]() ![]() ![]() Ideally, buy the items closest to the phase you are in. If you have to start collecting them from scratch then it will take quite a bit of work to cap out your poetics 3 times.ĭo yourself a favor, and buy the items NOW, rather than later. However, in phase 3 of the anima relic quest, you will need 6,000 poetics to buy all the Unidentifiable items required. However, the objective here is to maximize your poetics and GCS power, since those are both currencies that are frequently obtained through a variety of content but are commonly “wasted” because of the relatively low cap limits.įor example, you can only hold 2,000 poetics at a given time. These are not the only items you will need, nor are they only obtainable by this method. Purchasing any of the above items, beforehand, will drastically reduce the overall time it takes to grind out your anima relic weapon. It would behoove you to purchase the following items as soon as possible. Both of which are currencies that have a relatively small cap. ![]() Many of the phases require items that can be purchased with Allagan Tomestones of Poetics and Grand Company Seals(GCS). Fortunately, you can actually get much of the grind out of the way, before you even get to a particular phase. However, it can still be rather “grindy” if you don’t stay ahead of the quest items. Once all points have been allocated, Gerolt forges a new item level 240 weapon to contain the strenghtened Anima.Obtaining the final anima relic weapon is much faster than it was a few years ago. After 120 points have been allocated, there is a chance to obtain more Treated Crystal Sand, up to 6 pinches per conversion. It takes 240 growth points to complete the step and each pair of Umbrite and Crystal Sand converts into 3 pinches of Treated Crystal Sand. Umbrite can be obtained for 300 Allagan Tomestones of Esoterics from Hismena and Crystal Sand can be obtained from Ulan via item trade. To complete the quest "A Dream Fulfilled", Umbrites and Crystal Sand must be treated by Ulan in order to obtain Treated Crystal Sand, used to allocate growth points to the desired secondary stats. The coating will upgrade Anima Weapons to a "Hyperconductive" state, increasing item level to 230 and applying a new glowing particle effect when unsheathed.Īdded in Patch 3.3, the fifth step step involves increasing the Anima's growth and strength, but a new weapon is needed as the current weapon is not strong enough. This item can either be purchased with 1800 Allagan Tomestones of Esoterics, or obtained by completing the Crystal Tower quest "The Gift of the Archmagus" once per week. Gerolt requires five bottles of Aether Oil. Once all four materials, the Anima Weapon can be constructed, at item level 210.Īdded in Patch 3.25, the fourth step in upgrading is through the quest "Finding Your Voice". The latter are created with synthesis by specialist crafters, while the former can be obtained from a variety of sources, such as beast-tribe vendors, exchanging Allagan Tomestones, or collecting certain items from Alexander: Gordias. These materials can be bartered with Cristiana at Revenant's Toll, in exchange for the following items (as of Patch 3.38): To finalize the Anima Weapon, Gerolt needs four special materials: Enchanted Rubber, Fast-drying Carboncoat, Fast-acting Allagan Catalyst, and some Divine Water. The third step to create the full Anima Weapon is through the quest "Coming into its Own". The weapon will become "Awoken", at item level 200 and possesses a distinct glow effect with unsheathed. Once the Vault is completed, the weapon can be upgraded back at Azys Lla. Players will speak with Ardashir in a cutscene after the third, sixth, and tenth dungeon. The second phase is through the quest "Toughening Up." To fully awaken the experimental weapon, players must do the following dungeons in sequence with their Animated weapon equipped: This can be used for the next part.įinal Fantasy 7 Remake Intergrade Intermission Review - Half-Measure Once both nodules are presented to Ardashir, Gerolt will create an "animated" version of the Artifact Weapons at item level 170. For these, she requires three Luminous Crystals, of each element, obtained randomly from participating in FATEs in Heavensward areas.Īlternatively, a Zodiac Weapon Zeta can be sacrificed to obtain both nodules immediately and bypass obtaining the crystals. These two items are obtained from Syndony in Revenant's Toll. The first step is through the quest "Soul Without Life." Players must obtain two items for Gerolt to install on the weapon: an Astral Nodule and Umbral Nodule. The individual steps for each weapon can only done with one job at a time. 3.1 Sword of the Twin Thegns & Shield of the Twin Thegns (PLD). ![]() ![]() ![]() In this way, users' activity (or lack thereof) triggers a personal message that is customized to the user in their preferred platform. Marketing automation helped companies segment customers, launch multichannel marketing campaigns, and provide personalized information for customers., based on their specific activities. Marketing automation is the process by which software is used to automate conventional marketing processes. In 2007, marketing automation was developed as a response to the ever-evolving marketing climate. These problems encouraged marketers to find new ways to integrate digital technology into market development. In addition, a survey in 2000 in the United Kingdom found that most retailers had not registered their own domain address. In the 2000s, with increasing numbers of Internet users and the birth of iPhone, customers began searching products and making decisions about their needs online first, instead of consulting a salesperson, which created a new problem for the marketing department of a company. This led to the first clickable banner ad going live in 1994, which was the "You Will" campaign by AT&T and over the first four months of it going live, 44% of all people who saw it clicked on the ad. ![]() Marketers were also able to own online customer data through eCRM software after the Internet was born. Fierce competition forced vendors to include more service into their software, for example, marketing, sales and service applications. With the development of server/client architecture and the popularity of personal computers, Customer Relationship Management (CRM) applications became a significant factor in marketing technology. ![]() ![]() In the 1990s, the term digital marketing was coined. Databases allowed companies to track customers' information more effectively, transforming the relationship between buyer and seller. Companies started choosing online techniques, such as database marketing, rather than limited list broker. In the 1980s, the storage capacity of computers was already big enough to store huge volumes of customer information. Historyĭigital marketing effectively began in 1990 when the Archie search engine was created as an index for FTP sites. The extension to non-Internet channels differentiates digital marketing from online marketing. Digital marketing extends to non-Internet channels that provide digital media, such as television, mobile phones ( SMS and MMS), callback, and on-hold mobile ring tones. As digital platforms became increasingly incorporated into marketing plans and everyday life, and as people increasingly use digital devices instead of visiting physical shops, digital marketing campaigns have become prevalent, employing combinations of search engine optimization (SEO), search engine marketing (SEM), content marketing, influencer marketing, content automation, campaign marketing, data-driven marketing, e-commerce marketing, social media marketing, social media optimization, e-mail direct marketing, display advertising, e–books, and optical disks and games have become commonplace. Its development during the 1990s and 2000s changed the way brands and businesses use technology for marketing. ĭigital marketing is the component of marketing that uses the Internet and online based digital technologies such as desktop computers, mobile phones and other digital media and platforms to promote products and services. Advertising revenue as a percent of US GDP shows a rise in digital advertising since 1995 at the expense of print media. ![]() ![]() ![]() Additionally, each organization (or their contracted food service company) must submit annual registration fees to the Office of Environmental Health and Safety in order to operate food service in a chapter house. Kitchen inspections are conducted annually by the Office of Environmental Health and Safety (EHS) professional staff to ensure the housed organization is compliant with Title 410-IAC-7-24 Retail Food Establishment Sanitation Requirements. Failure to pass such inspections may result in closure of the facility until the issues identified in the inspection are appropriately corrected and the organization successfully passes the inspection and/or drills. Housed organizations must pass fire safety inspections and fire drills conducted by INLOCC. Inspections can occur more than once a year.įire safety inspections are conducted annually by the Office of Insurance, Loss Control and Claims (INLOCC) for compliance with applicable Indiana Fire Code and NFPA standards as adopted by the State of Indiana. Sorority and fraternity facilities are required to be inspected annually by a private vendor for the following environmental health and safety concerns: pest control, mold, sanitation, asbestos, lead paint, hazardous materials, drinking water, ventilation, indoor air quality (including radon), and conditions associated with, or that may lead to, the spread of communicable diseases. EHS and INLOCC staff will identify themselves and will state why they are entering. No room will be entered without knocking. Sorority and fraternity facilities are subject to the following university regulations and policies:Įnvironmental Health and Safety (EHS) and Insurance, Loss Control and Claims (INLOCC) professional staff have the right to enter and inspect relevant parts of the sorority or fraternity facility, including private rooms if necessary, for the purpose of conducting fire safety and kitchen inspections. Each student residing in a sorority and fraternity facility must abide by Indiana University policies, including the OSFL Recognition Policy, the OSFL Social Events Policy, the University Recognized Housing Policy, and the IU Code of Student Rights, Responsibilities, and Conduct. Housed Sorority and Fraternity Rules and RegulationsĮach housed sorority and fraternity set their own live-in and live-out housing leases, bylaws, house rules, move-in dates, and move-out deadlines. Questions or requests for specific information about a chapter facility should be directed to the House Corporation Board President or Chapter Advisor for the organization. Each housed organization operates independently with housing leases between the students and the organization. ![]() These chapter facilities are privately owned and operated by local House Corporation Boards or Inter/National Headquarters.Īll House Corporation Boards are not-for-profit corporations, many of which are operated by alumni volunteers. The Sorority and Fraternity Community is the largest it has ever been, and nearly half of its members live in 40 different chapter houses. Consequences of Suspension and Expulsion.Emergency Financial Assistance for Students.Scholarships for Students with Disabilities.Military Withdrawal & Leaves of Absence.Disability-Related Accommodation Agreement. ![]() ![]() KEYTRUDA is indicated for the treatment of patients with unresectable or metastatic melanoma. Selected KEYTRUDA ® (pembrolizumab) Indications in the U.S. The KEYTRUDA clinical program seeks to understand the role of KEYTRUDA across cancers and the factors that may predict a patient's likelihood of benefitting from treatment with KEYTRUDA, including exploring several different biomarkers. There are currently more than 1,300 trials studying KEYTRUDA across a wide variety of cancers and treatment settings. Merck has the industry’s largest immuno-oncology clinical research program. KEYTRUDA is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2, thereby activating T lymphocytes which may affect both tumor cells and healthy cells. KEYTRUDA is an anti-PD-1 therapy that works by increasing the ability of the body’s immune system to help detect and fight tumor cells. In Europe alone, it is estimated there were nearly 500,000 new cases of colorectal cancer.Ībout KEYTRUDA ® (pembrolizumab) Injection, 100 mg It is estimated there were about 1,850,000 new cases of colorectal cancer globally in 2018. Colorectal cancer is the third most commonly diagnosed cancer and the second most common cause of cancer-related death worldwide. Colorectal cancer often begins with growths on the inner lining of the colon or rectum called polyps, which can change into cancer over time. It is estimated approximately 5-15% of colorectal cancer patients have tumors that score as either MSI-H or dMMR when testing is performed.Ĭolorectal cancer starts in the colon or the rectum, and these cancers are referred to as colon cancer or rectal cancer depending on where the cancer starts. This defect is also referred to as mismatch repair deficiency (dMMR). The cause of MSI may be a defect in the ability to repair mistakes made when DNA is copied in the cell. Microsatellite instability (or MSI) is defined by the National Cancer Institute as a change that occurs in the DNA of certain cells, such as tumor cells, in which the number of repeats of microsatellites (short, repeated sequences of DNA) is different from the number of repeats that was in the DNA when it was inherited. The CHMP’s recommendation will now be reviewed by the European Commission for marketing authorization in the European Union, and a final decision is expected in the first quarter of 2021. “This positive EU CHMP opinion reinforces the potential of KEYTRUDA as a new option for patients with MSI-H/dMMR colorectal cancer and illustrates our ongoing commitment to pursuing biomarker research to help address the needs of patients who have few effective options.”ĭata from KEYNOTE-177 were presented at the virtual scientific program of the 2020 American Society of Clinical Oncology Annual Meeting and were published in The New England Journal of Medicine. ![]() Vicki Goodman, vice president, clinical research, Merck Research Laboratories. “Patients in Europe with MSI-H/dMMR colorectal cancer have had only chemotherapy-containing regimens available to them in the first-line treatment setting and have historically faced poor outcomes,” said Dr. This recommendation is based on results from the pivotal Phase 3 KEYNOTE-177 trial, in which KEYTRUDA, as a monotherapy, demonstrated a significant improvement in progression-free survival compared to chemotherapy (investigator’s choice: mFOLFOX6 with or without bevacizumab or cetuximab or FOLFIRI with or without bevacizumab or cetuximab), a current standard of care. KENILWORTH, N.J.-( BUSINESS WIRE)-Merck (NYSE: MRK), known as MSD outside the United States and Canada, announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has adopted a positive opinion recommending approval of KEYTRUDA, Merck’s anti-PD-1 therapy, as monotherapy for the first-line treatment of adult patients with metastatic microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) colorectal cancer. ![]() ![]() ![]() These programs introduced many to the browser concept and 20 years later, Google still lists 3,000,000 references to PC Hypertext. In 1986, he released his DOS Houdini knowledge network program that supported 2500 topics cross-connected with 7500 links in each file along with hypertext links among unlimited numbers of external ASCII, batch, and other Houdini files, these capabilities were included in his then popular shareware DOS file browser programs HyperRez (memory resident) and PC Hypertext (which also added jumps to programs, editors, graphic files containing hot spots jumps, and cross-linked thesaurus/glossary files). In 1984, expanding on ideas from futurist Ted Nelson, Neil Larson's commercial DOS MaxThink outline program added angle bracket hypertext jumps (adopted by later web browsers) to and from ASCII, batch, and other MaxThink files up to 32 levels deep. This was the first web browser aiming to bring multimedia content to non-technical users, and therefore included images and text on the same page, unlike previous browser designs its founder, Marc Andreessen, also established the company that in 1994, released Netscape Navigator, which resulted in one of the early browser wars, when it ended up in a competition for dominance (which it lost) with Microsoft's Internet Explorer (for Windows). The explosion in popularity of the Web was triggered in September 1993 by NCSA Mosaic, a graphical browser which eventually ran on several popular office and home computers. Today, the major web browsers are Chrome, Safari, Internet Explorer, Firefox, Opera, and Edge. Many others were soon developed, with Marc Andreessen's 1993 Mosaic (later Netscape), being particularly easy to use and install, and often credited with sparking the internet boom of the 1990s. Precursors to the web browser emerged in the form of hyperlinked applications during the mid and late 1980s, and following these, Tim Berners-Lee is credited with developing, in 1990, both the first web server, and the first web browser, called WorldWideWeb (no spaces) and later renamed Nexus. Hyperlinks present in resources enable users easily to navigate their browsers to related resources.Ī web browser can also be defined as an application software or program designed to enable users to access, retrieve and view documents and other resources on the Internet. ![]() This may be a web page, image, video, or other piece of content. The method of accessing a particular page or content is achieved by entering its address, known as a Uniform Resource Identifier or URI. It further provides for the capture or input of information which may be returned to the presenting system, then stored or processed as necessary. For the "history" feature found in most web browsers, see Web browsing history.Ī web browser is a software application for retrieving, presenting and traversing information resources on the World Wide Web. ![]() |